Program
Program 2019
30th Ion Channel Meeting
September 8th through 11th 2019,
Sète, France
Sunday, September 8th 2019
16:00 – 19:00 Welcome of the meeting attendees
19:00 Welcome drink and Dinner
21:00 Plenary lecture
Anne Feltz (Institute of Biology of Ecole Normale Supérieure, Paris)
“30 years of ion channel history”
Monday, September 9th 2019
08:15 Opening session
08:30 Symposium 1: “Ionic channels and autism”
Organized by Jean-Louis Bossu (Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, France)
Diane Papazian (Los Angeles, USA): Altered gating in mutant Kv4.2 channel associated with autism and epilepsy
Igor Medina (Marseille, France) : Causal links between impaired developmental neuronal chloride homeostasis and formation of Autistic Spectrum Disorders
Enrico Cherubini (Roma, Italy) : Impairment of GABAergic signalling in Autism Spectrum Disorders
Selected speaker: Eric Hosy (Bordeaux, France): Nanoscale co-organization and co-activation of AMPAR, NMDAR and mGluR at the synapse
10:15 Coffee break
10:30 Oral communication session 1: "New insights in ion channels pharmacology"
Organized by Sylvie Diochot (IPMC, University of Nice-Sophia Antipolis, France)
Ines ELBini Dhouib (Tunis, Tunisia): Potential neuroprotective effect of bee venom on aluminum chloride-induced Alzheimer's disease on rats
Zhong Peng (Lausanne, Switzerland): Acid-sensing ion channels of the hypothalamus are regulated by hydrogen sulphide.
Léa Réthoré (Angers, France): BREVENAL PREVENTS CIGUATOXIN AND BREVETOXIN ACTIVATION OF NAV CHANNELS..
Osbaldo Lopez-Charcas (Tours, France): Biophysical characterization of new small-molecule blockers of nNaV1.5 channels expressed in breast cancer cells
11:30 1-minute oral presentation for posters
12:15 Lunch
14:00 Poster session 1
15:30 Poster session 2
17:00 Symposium 2: “Ion channels and skin functions”
Organized by Aubin Penna (Laboratoire STIM, University of Poitier, France)
Hongzhen HU (St. Louis, USA): "Cutaneous ion channel mechanisms of itch signaling".
V'yacheslav LEHEN’KYI (Lille, France): TRP channels and Skin homeostasis.
Elena OANCEA (Providence, USA): "Intracellular ion channels that regulate skin pigmentation".
Selected speaker: Adélaïde Doray (Tours, France): The role of the auxiliary NaVβ4 subunit in maintaining epithelial phenotype
18:30 Annual meeting of the association « Canaux ioniques »
19:30 Apéritif Sétois
20:30 Dinner
Tuesday, September 10th 2019
08:30 Symposium 3: Glutamate ligand-gated channels
Organized by Laurent Fagni (IGF, University of Montpellier, France)
Pierre Paoletti (Paris, France): New types of NMDA receptors
Christophe Mulle (Bordeaux, France): Kainate receptors in temporal lobe epilepsy: a translational journey
Ludovic Tricoire (Paris, France): The delta family of glutamate receptors: role in excitatory synaptic transmission
Selected speaker: Perrine Inquimbert (Strasbourg, France): Plasticity of inhibitory synaptic transmission under the control of NMDA receptors in the dorsal horn of the spinal cord
10:15 Coffee break
10:30 Symposium 4: Ion channels in cancer therapy resistance
Organized by Lise Rodat-Despoix (LPCM, University of Amiens, France)
Federica Wolf (Roma, Italy): Magnesium-Specific Ion Channels in Chemoresistance: Is There a Role for Magnesium?
Geert Bultynck (Leuven, Belgium): Ca2+-signaling modulation by anti-apoptotic Bcl-2 proteins: from molecular mechanisms towards translational avenues
Annarosa Arcangeli (Florence, Italy): Targeting potassium channels to overcome chemoresistance in gastrointestinal cancers
Selected speaker: Charlotte Dubois (Lille, France): Apoptosis mediated by Mitochondrial Ca2+ Overload Requires Inhibition of Autophagy Revealing a Widespread Vulnerability of Cancer Cells
12:15 Lunch
14:00 Special social events for 30th anniversary of association « Canaux ioniques » : Boat excursion with Sète Croisières : One hour guided tour of the fishing port, commercial port and marina, followed by a sea excursion along the rocky 'corniche' with underwater viewing. (http://www.sete-croisieres.com/).
19:00 Poster Prize session
19:30 Apéritif and special dinner
22:00 Evening Party
Wednesday, September 11th 2019
09:30 Oral communication session 2
Organized by Dimitra Gkika (Laboratoire de Physiologie Cellulaire, University of Lille, France)
Olivier Bignucolo (Lausanne, Switzerland): BIOMOLECULAR MODELLING OF ACID-SENSING ION CHANNELS
Côme Camus (Bordeaux, France): PHOSPHORYLATION OF PSD95 AS POTENTIAL LINK BETWEEN SYNAPTIC AND STRUCTURAL PLASTICITIES
Mathilde Folacci (Grenoble, France): Design of light-modulated inward rectifying potassium channels
Kerstin K. Viet (Frankfurt am Main, Germany): Structure and Ca2+ interaction of the Extracytosolic/Lumenal Domain (ELD) of the human TRPML2 ion channel
10:30 Coffee break
10:45 Symposium 5: “A-typical” Ion channels/currents
Organized by Pietro Mesirca (IGF, University of Montpellier, France)
Rajan Sah (Iowa City, USA): SWELL1/LRRC8a mediated nutrient sensing.
Arnaud Monteil (Montpellier, France): The sodium leak channel: NALCN.
Anna Moroni (Milan, Italy): Engineering synthetic tools for the inhibition of cell excitability.
Selected speaker: Mallory Ducrozet (Lyon, France): Role of Translocon in calcium exchanges in cell compartments and in cell death, during myocardial infarct
12:30 Meeting closure
13:15 Lunch
14:00 Airport shuttle departure
Program
- Details
29th Ion Channel Meeting
September 9th through 12th, Sète, France
Sunday, September 9th 2018
16:00 – 20:00 Welcome of the meeting attendees
20:00 Welcome drink and Dinner
Monday, September 10th 2018
08:30 Opening session
08:45 Symposium 1: Role of ion channels in cytoskeleton dynamic and cell migration
Organized by Bruno Constantin (Laboratoire STIM, University of Poitiers, France
Francisco Javier Martin-Romero (Badajoz, Spain): Regulation of cortical cytoskeleton dynamics and cell migration by STIM1 and ORAI1.
Alessandra Fiorio Pla (Milano, Italy) TRPM8 inhibits cell adhesion and migration by trapping the small GTPase RAP1: Common target for cancer cell invasion and vascularization
Lise RODAT-DESPOIX (Amiens, France) IP3R3 in breast cancer cells: Turning calcium oscillations into migratory skills.
Selected speaker: Frederic Gradek (Tours, France) Nav1.5 Voltage-gated sodium channels enhance mesenchymal breast cancer cells invasiveness.
10:30 Coffee break
11:00 Oral communication session1: « Ion channels and pathophysiology»
Organized by Thierry Chataigneau (Laboratoire CAMB, University of Strasbourg, France)
Alexandru Babes (Bucharest, Romania): TRPA1 and TRPV1 channels are involved in 7-dehydrocholesterol-induced photosensitization in the Smith-Lemli-Optiz syndrome.
Kjara Sophia Pilch (Bordeaux, France): Novel transgenic P2X4MCHERRYIN KNOCKIN mice expressing non-internalized P2X4 receptors reveal alterations in hippocampal plasticity and memory.
Philippe Lory (Montpellier, France): De novo mutation screening in Childhood Cerebellar Atrophy(ChCA) identifies gain of function mutations in the Cav3.1 T-type calcium channel.
Osbaldo Lopez-Charcas (Tours, France): The invasiveness of human cervical cancer associated to the function of Nav1.6 channels is mediated by MMP-2 activity 1.
12:15 1-minute oral presentation for odd number posters
12:45 Lunch
15:00 Poster session 1
17:00 Symposium 2: Physiopathology of cardiac pacemaker activity and biological pacemakers
Organized by Matteo Mangoni (IGF, University of Montpellier, France)
Ana M Gomez (Chatenay, France): Calcium handling in Pacemaker cells from catecholaminergicpolymorphic ventricular tachycardia mice models.
Mark Boyett (Manchester, UK): Plasticity of ion channel expression in the sinus node.
IRA Cohen (Stony Brook, USA): How to build a biological pacemaker?
Selected speaker: Adrien Moreau (Lyon, France): Arrythmogenic cardiomyopathy in a dish based onpatient specific induced pluripotent cell.
18:45 Plenary lecture
Denis Noble (Oxford, GB)
“FROM PACING THE HEART TO THE PACE OF EVOLUTION”
20:00 Dinner
Tuesday, September 11th 2018
08:45 Symposium 3: Toxins and natural tools: towards their uses in Public Health
Organized by Sylvie Diochot (IPMC, University of Nice-Sophia Antipolis, France)
Lachlan D. Rash (Brisbane, Australia): The structure function relationships of closed state acidsensing
ion channel inhibitors.
Tânia C. Gonçalves (Saclay, France): Antinociceptive evaluation of cyriotoxin-1a and huwentoxin-IV,
two spider toxins that block with high affinity the Nav1.7 subtype of voltage-gated sodium channels.
Steve Peigneur (Leuven, Belgium): Marine organisms as a rich source for novel modulators of the
Cancer-Relevant Potassium Channel KV10.1.
Selected speaker: Antony Chung You Chong (Montpellier, France): Inhibition of KACh channels by
the bee venom peptide tertiapin-Q rescues cardiac conduction and sino-atrial bradycardia in models of
congenital bradycardia.
10:30 Coffee break
11:00 Oral communication session 2: «"Role of ionic channels in cerebral physiology and
pathology"
Organized by Nathalie Rouach (Collège de France, Paris-France)
Cheng-Chang Lien (Taipei, Taiwan): Connectivity and function of a longitudinal hippocampal
circuitry.
Chung-Jiuan Jeng (Taipei, Taiwan): Proteostatic mechanism of Eag1 potassium channel.
Domiziana Ortolani (Paris, France): An In Vivo Optogenetic Approach to Study Neuron-
Oligodendroglia Interactions in Mouse Pups.
Claire Soulard (Montpellier, France): Regulation of motor capacity by TMEM16F, a chloride channel
expressed in motoneurons. What impact for ALS?
12:15 Sponsor Communication: Cambridge Electronic Design, Ltd
12:30 1-minute oral presentation for even number posters
13:00 Lunch
15:00 Poster session 2
17:00 Symposium 4: Regulation of ion channels by steroids and lipids
Organized by Dimitra Gkika (Laboratoire PhyCell, University of Lille, France)
Marie Potier-Cartereau (Tours, France): The ether lipid-sensitive SK3 channel in cancer.
Johannes Oberwinkler (Marburg, Germany): Regulation of the steroid-sensitive ion channels TRPM3
and TRPM1.
Isabella Derler (Linz, Austria): Cholesterol modulates Orai1 channel function.
Selected speaker: Fanny Salmeron (Montpellier, France): Do DHA open TREK-1 channels or is it
NEO-PUFAs?
18:45 Annual meeting of the association « Canaux ioniques »
19:30 Apéritif Sétois and special dinner
21:30 Poster and Oral Communication Prize session
22:00 Evening Party
Wednesday, September 12th 2018
08:45 Symposium 5: Regulation of potassium channels in physiology and pathology
Organized by Raphaël Rapetti-Mauss (IBV, University of Nice Sophia Antipolis, France)
Geoffrey W. Abbott (Irvine, USA): Direct neurotransmitter activation of voltage-gated ion channels.
Guillaume Sandoz (Nice, France): Heteromerization of K2P channels: from physiology to
physiopathology
Michael Puljung (Oxford, UK): Visualizing nucleotide regulation of the KATP channel.
Selected speaker: Corinna J. Mohr (Tuebingen, Germany): Big conductance calcium-activated
potassium (BK) channels in hormone-based development and therapy of breast cancer.
11:15 Coffee break
11:30 Symposium special : Taiwan Channel and Neuroscience Consortium
Organized by Emmanuel Deval (IPMC, University of Nice-Sophia Antipolis, France) and sponsored by
the France-Taiwan ORCHID partnership
Chun-Hsiang Tan (Taipei, Taiwan): The TRPM2 ion channel is required for sensitivity to warmth.
Chih-Cheng Chen (Taipei, Taiwan): Genetic exploration for roles of acid-sensing ion channels in
somatosensory system.
Chi-Kuang Yao (Taipei, Taiwan): Flower Ca2+ channel elevates phosphatidylinositol 4,5 biphosphate
to govern synaptic vesicle recycling via activity-dependent bulk endocytosis.
Shi-Bing Yang (Taipei, Taiwan): Biophysical characterization of the pH-sensing mechanism for
TALK1 channel.
13:00 Meeting closure
13:15 Lunch
14:00 Airport shuttle departure
Preliminary Program
- Details
This year, the meeting will be organized around 5 symposia, a plenary lecture and a special session gathering young scientists from Taiwan.
The following speakers agreed to come
Plenary lecture : Denis Noble (Oxford, GB)
Role of ion channels in cytoskeleton dynamic and cell migration
Organized by Bruno Constantin
- F-J Martin-Romero (Badajoz, Spain)
- A Fiorio Pla (Milano, Italy)
- L Rodat Despoix (Amiens, France)
Regulation of potassium channels in physiology and pathology
Organized by Raphaël Rapetti-Mauss
- G Abbott (Irvine, USA)
- G Sandoz (Nice, France)
- M Puljung (Oxford, UK)
Physiopathology of cardiac pacemaker activity and biological pacemakers
Organized by Matteo Mangoni
- A-M Gomez (Chatenay, France)
- M Boyett (Manchester, UK)
- I Cohen (Stony Brook, USA)
Regulation of ion channels by steroids and lipids
Organized by Dimitra Gkikka
- M Potier-Cartereau (Tours, France)
- J Oberwinkler (Marburg, Germany)
- I Derler (Linz, Austria)
Toxins and natural tools: towards their uses in Public Health
Organized by Sylvie Diochot
- L Rash (Brisbane, Australia)
- T Goncalves (Saclay, France)
- S Peigneur (Leuven, Belgium)
Taiwan Channel and Neuroscience Consortium
Organized by Emmanuel Deval and sponsored by the France-Taiwan ORCHID partnership
C-Hs Tan, C-C Chen, C-KYao, S-B Yang (Academia Sinica, Taiwan)